Lawrence L. Selks Named Instructor of Communication Arts and Assistant Director of the UD Players

News release announcing Lawrence L. Selks, former director of Family Plays at Ohio State University, has been named Instructor of Communication Arts and Assistant Director of the UD Players Company at the University of Dayton

Performanz Evaluation von PQC in TLS 1.3 unter variierenden Netzwerkcharakteristiken

Quantum computers could break currently used asymmetric cryptographic schemes in a few years using Shor's algorithm. They are used in numerous protocols and applications to secure authenticity as well as key agreement, and quantum-safe alternatives are urgently needed. NIST therefore initiated a standardization process. This requires intensive evaluation, also with regard to performance and integrability. Here, the integration into TLS 1.3 plays an important role, since it is used for 90% of all Internet connections. In the present work, algorithms for quantum-safe key exchange during TLS 1.3 handshake were reviewed. The focus is on the influence of dedicated network parameters such as transmission rate or packet loss in order to gain insights regarding the suitability of the algorithms under corresponding network conditions. For the implementation, a framework by Paquin et al. was extended to emulate network scenarios and capture the handshake duration for selected algorithms. It is shown that the evaluated candidates Kyber, Saber and NTRU as well as the alternative NTRU Prime have a very good overall performance and partly undercut the handshake duration of the classical ECDH. The choice of a higher security level or hybrid variants does not make a significant difference here. This is not the case with alternatives such as FrodoKEM, SIKE, HQC or BIKE, which have individual disadvantages and whose respective performance varies greatly depending on the security level and hybrid implementation. This is especially true for the data-intensive algorithm FrodoKEM. In general, the prevailing network characteristics should be taken into account when choosing scheme and variant. Further it becomes clear that the performance of the handshake is influenced by external factors such as TCP mechanisms or MTU, which could compensate for possible disadvantages due to PQC if configured appropriately.Comment: Master's thesis, 160 pages, in Germa

Towards Managing the Migration to Post-Quantum-Cryptography

As soon as cryptographically relevant quantum computers exist, they can break today's prevalent asymmetric cryptographic algorithms. Organizations (and the IT society) have to plan on migrating to quantum-resilient cryptographic measures, also known as post-quantum cryptography (PQC). However, this is a difficult task, and to the best of our knowledge, there is no generalized approach to manage such a complex migration for cryptography used in IT systems. PMMP helps organizations manage the migration to PQC and establish crypto-agility. Having finished the initial theoretical design phase, we are now looking to promote PMMP to encourage practitioners to join the effort and work with us to develop it further.Comment: 20 page

Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1

Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70S6K1-dependent protein phosphorylation, β-TrCP1-mediated ubiquitination, and proteasomal destruction. Following high-throughput screening of natural product extract libraries using a luciferase-based reporter assay to monitor phosphorylation-dependent proteasomal degradation of the tumor suppressor Pdcd4, we succeeded in showing that a crude extract from Eriophyllum lanatum stabilized Pdcd4 from TPA-induced degradation. Erioflorin was identified as the active component and inhibited not only degradation of the Pdcd4-luciferase-based reporter but also of endogenous Pdcd4 at low micromolar concentrations. Mechanistically, erioflorin interfered with the interaction between the E3-ubiquitin ligase β-TrCP1 and Pdcd4 in cell culture and in in vitro binding assays, consequently decreasing ubiquitination and degradation of Pdcd4. Interestingly, while erioflorin stabilized additional β-TrCP-targets (such as IκBα and β-catenin), it did not prevent the degradation of targets of other E3-ubiquitin ligases such as p21 (a Skp2-target) and HIF-1α (a pVHL-target), implying selectivity for β-TrCP. Moreover, erioflorin inhibited the tumor-associated activity of known Pdcd4- and IκBα-regulated αtranscription factors, that is, AP-1 and NF-κB, altered cell cycle progression and suppressed proliferation of various cancer cell lines. Our studies succeeded in identifying erioflorin as a novel Pdcd4 stabilizer that inhibits the interaction of Pdcd4 with the E3-ubiquitin ligase β-TrCP1. Inhibition of E3-ligase/target-protein interactions may offer the possibility to target degradation of specific proteins only as compared to general proteasome inhibition

White Paper: Open Digital Health – accelerating transparent and scalable health promotion and treatment

In this White Paper, we outline recommendations from the perspective of health psychology and behavioural science, addressing three research gaps: (1) What methods in the health psychology research toolkit can be best used for developing and evaluating digital health tools? (2) What are the most feasible strategies to reuse digital health tools across populations and settings? (3) What are the main advantages and challenges of sharing (openly publishing) data, code, intervention content and design features of digital health tools? We provide actionable suggestions for researchers joining the continuously growing Open Digital Health movement, poised to revolutionise health psychology research and practice in the coming years. This White Paper is positioned in the current context of the COVID-19 pandemic, exploring how digital health tools have rapidly gained popularity in 2020-2022, when world-wide health promotion and treatment efforts rapidly shifted from face-to-face to remote delivery. This statement is written by the Directors of the not-for-profit Open Digital Health initiative (n = 6), Experts attending the European Health Psychology Society Synergy Expert Meeting (n = 17), and the initiative consultant, following a two-day meeting (19-20th August 2021).Peer reviewe

Außerschulische Lernorte von Kindern : Reflexionen - Konzeptionen - Perspektiven

Weitere Hrsg.: Martin Gröger, Daria Johanna Schneider, Jutta Wiesemann. Publikation anlässlich der Tagung „Orte und Räume der Generationenvermittlung – Außerschulisches Lernen von Kindern“, Universität Siegen, 5.-6. Oktober 2017Die Wertschätzung des außerschulischen Lernens hat in der Schulpädagogik eine lange Tradition und ist besonders in der Grundschule und im Sachunterricht etabliert. Mit einem Blick auf Möglichkeiten der Vernetzung schulischer und außerschulischer Lernwelten rückt das Bildungspotenzial und die Bildungswirksamkeit außerschulischer Lernorte zunehmend in den Aufmerksamkeitsfokus bildungspolitischer, schulpädagogischer sowie didaktischer Reflexion. Eine Gelegenheit zu einer vertieften Auseinandersetzung mit diversen außerschulischen Lernarrangements bot die Tagung zum Thema „Orte und Räume der Generationenvermittlung – außerschulisches Lernen von Kindern“, die im Oktober 2017 an der Universität Siegen stattfand. Die vielfältigen Impulse und wertvollen Überlegungen der Tagungsteilnehmerinnen und -teilnehmer werden in der vorliegenden Publikation „Außerschulische Lernorte von Kindern – Reflexionen – Konzeptionen – Perspektiven“ aufgegriffen. Die Beiträge des Bandes gliedern sich in drei Themenblöcke: zum einen werden konzeptionelle Überlegungen zum außerschulischen Lernort vorgestellt, zum anderen eröffnet der Band Einblicke in die Entwicklung und Ausgestaltung sowie in den Einsatz von Materialien am außerschulischen Lernort. Der dritte Themenblock gibt abschließend einige Beispiele für die mannigfaltigen Möglichkeiten, schulische und außerschulische Lernorte effektiv zu vernetzen

Solar Decathlon 2009

Entwurf, Ausführung, Entwicklung und Bau eines energiegewinnenden Prototypen für zukunftsorientiertes Wohnen im Jahr 2015 im Rahmen des Solar Decathlon 2009